Ketamine Therapy for Treatment-Resistant Depression and Anxiety: A Doctor’s Perspective on Safety and Potential Benefits

In the realm of mental health treatment, the landscape is constantly evolving, with researchers and clinicians exploring innovative approaches to address conditions like treatment-resistant depression and anxiety. Over the last 20 years research has been done with ketamine for patients who have not gotten relief with traditional antidepressants and anti-anxiety medicines and over the last 5 years building off of this mounting evidence, physicians have started to provide Ketamine in monitored settings for patients undergoing treatment. 

As a medical professional, I aim to shed light on the safety considerations and potential benefits of ketamine therapy for individuals struggling with persistent depression and anxiety.

Ketamine has long been recognized for its anesthetic properties and analgesic effects. However, recent studies have unveiled its remarkable potential in treating mental health conditions, particularly when traditional approaches have proven ineffective. It’s important to note that the use of ketamine for mental health concerns is typically done in a controlled and supervised clinical setting, administered by qualified healthcare professionals.

Safety is a paramount concern in any medical treatment, and ketamine therapy is no exception. When administered responsibly under the guidance of a medical doctor, ketamine has shown a favorable safety profile. The dosages used for mental health treatment are typically much lower than those used in surgical procedures, minimizing the risk of adverse effects. Patients are carefully screened for any contraindications, and their medical history is thoroughly evaluated to ensure the suitability of ketamine therapy for their specific condition.

One of the primary advantages of ketamine therapy is its rapid onset of action. Traditional antidepressants can take weeks or even months to manifest their effects, leaving individuals grappling with the debilitating symptoms of depression and anxiety. Ketamine, on the other hand, has been shown to produce noticeable improvements in mood and anxiety levels within hours of administration. This rapid response is particularly beneficial for those in acute distress or facing a crisis.

Moreover, ketamine acts on a different neurotransmitter system compared to conventional antidepressants. While most antidepressants primarily target serotonin, ketamine influences the glutamate system, leading to the release of neurotrophic factors that promote the growth of new synaptic connections. This unique mechanism of action provides a fresh perspective on treatment options for individuals who have not responded well to traditional approaches.

Another noteworthy aspect of ketamine therapy is its potential to alleviate suicidal ideation. For those facing the darkest depths of depression, the relief provided by ketamine can be transformative. Research has shown that ketamine rapidly reduces suicidal thoughts, offering a glimmer of hope to individuals who may have exhausted conventional treatment options.

It’s crucial to emphasize that ketamine therapy is not a standalone solution but rather a valuable tool in a comprehensive treatment plan. Counseling, psychotherapy, and ongoing support are integral components that complement the benefits of ketamine. The goal is to create a holistic approach that addresses the multifaceted nature of mental health.

As with any medical intervention, potential risks and side effects exist, but they are generally mild and transient when ketamine is administered in a controlled environment. These may include dissociation, increased heart rate, and elevated blood pressure during the infusion. The close monitoring by medical professionals ensures prompt intervention if any adverse reactions occur.

In conclusion, ketamine therapy presents a promising avenue for individuals grappling with treatment-resistant depression and anxiety. Its safety profile, rapid onset of action, and unique mechanism of action make it a compelling option for those who have not found relief through traditional methods. However, it is imperative that individuals considering ketamine therapy do so under the guidance of a qualified medical professional, ensuring a personalized and monitored approach to treatment. As the field of mental health continues to evolve, embracing innovative and evidence-based interventions like ketamine therapy may pave the way for renewed hope and healing.

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Dr. Tanya Dall and Dr. Justin Yanuck,  Renew Ketamine Infusion

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Obsessive Compulsive disorder (OCD) is unfortunately resistant to many forms of medical treatment including both medication and therapy.

Ketamine has been shown to be an effective, fast acting, safe option for patients with OCD. Over the course of the Ketamine infusions (2-4 weeks) neuroplasticity can lead to a change or abatement in the intrusive, repetitive thoughts and behaviors that typify OCD.

When combined with our unique post infusion integration process, patients with severe OCD can see profound relief of their symptoms.

Start here for a free physician consultation to see if Ketamine assisted psychotherapy can help renew you.

Chronic Pain

“There is extensive research currently being done on this topic. I can say from personal experience as a practicing Board Certified Pain Medicine Physician, I have had patients with chronic pain, including fibromyalgia, who have had significant relief of their symptoms with Ketamine assisted therapy. With that said, Ketamine assisted therapy will definitely not work for everyone with chronic pain, and each patient will require a thorough evaluation to ensure they are an adequate candidate for a trial of Ketamine assisted therapy for relief of their chronic pain” -Dr. Justin Yanuck.

The current evidence of Ketamine assisted therapy for chronic pain is fairly mixed. The majority of studies only looked at ketamine infusion without any assisted psychotherapy.

Ketamine has the ability to lead to relief on its own (and the mechanisms for this have been well studied). We feel quite strongly that the real potential for Ketamine to provide relief, especially for chronic pain patients, is when combined with psychotherapy. Psychotherapy allows the individual to process their experience and build off this experience to lead to new psychological frameworks for processing both internal and external stimuli.

Pain is complex, and Ketamine assisted psychotherapy is not one-size-fits-all. Our treatment plan gives patients with treatment-resistant chronic pain and even opiate dependance a chance to try a different and effective treatment. Start here (button) for a free physician consultation to see if Ketamine assisted psychotherapy can help renew you.

Start here for a free physician consultation to see if Ketamine assisted psychotherapy can help renew you.


Post Traumatic Stress Disorder (PTSD) is a major public health concern, affecting up to 7% of Americans.

As many as half of all Americans with PTSD get inadequate relief from traditional treatments which include antidepressants, antipsychotics, and cognitive behavioral therapy.

Ketamine combined with psychotherapy has been shown to be very effective at reducing the symptoms of PTSD. These effects last well beyond its near immediate relief.

Many mechanistic actions for how Ketamine works in PTSD have been proposed.

Ketamine allows people to reacquaint themselves with their past inciting trauma from an emotionally neutral perspective. Ketamine will not make you forget about the trauma. It can allow you to acknowledge its occurrence in a neutral way in order to not be continually re-traumatized by thinking about it.

Depending on the patient, outcomes can be noticed almost immediately with a sense of lightness and joy. Ketamine followed by psychotherapy has been shown to lead to significant relief of the burdens of PTSD.

Start here for a free physician consultation to see if Ketamine assisted psychotherapy can help renew you.


Traditional treatments for anxiety will often either work poorly, have addictive properties, or severe side effects including brain fog and drowsiness. Furthermore, these treatments tend to have reduced efficacy over time, and lead to only transient relief of symptoms.

Ketamine, when combined with our novel integrative psychotherapy, can lead to significant relief of anxiety.

During the ketamine infusion and integration process, patients will often get a better understanding of their anxiety, and are able to reframe many of the triggers that often provoke their anxiety.

Ketamine has properties that allow for rewiring of the brain (new synapse formation and repair of existing synapses). Ketamine allows people to effect changes into their own lives. It shows people that they have the power to heal from within and take control of their relationship with anxiety.

Start here for a free physician consultation to see if Ketamine assisted psychotherapy can help renew you.


Ketamine has been shown to be extremely effective and safe for patients with depression and treatment resistant depression (those who fail to get relief from two or more antidepressants).

Ketamine is highly effective at rapidly (within 2-8 hours) reducing depressive symptoms. Traditional antidepressants often take weeks to months to work.

Many traditional antidepressants have side effects including reduced libido, weight gain, GI upset, mood disturbances, and unfortunately require daily use for months to years.

Many antidepressants, even if they do work, require you to be on them for years, if not for the rest of your life.

Ketamine treatment has been shown in most patients to lead to resolution of symptoms without the need for any further medications.

Ketamine is not a medication meant to be taken for the rest of your life. The goal is to provide sustained relief after the completion of a set treatment plan. This is accomplished by combining the actions of Ketamine in the brain with psychotherapy. Additional enhancement sessions available as needed.

Unfortunately, there is a significant subset of patients that do not get significant relief from traditional cognitive behavioral therapy. Ketamine acts as a catalyst to stimulate a patient’s innate capacity for psychological healing. This allows patients to overcome past experiences and learned behavior to truly heal. Ketamine, combined with therapists who are specifically trained to work with psychedelic therapies, can lead to profound breakthroughs and deep psychological healing.

Start here for a free physician consultation to see if Ketamine assisted psychotherapy can help renew you.

Ketamine infusion combined with integrative therapy to help you renew your outlook

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