What Does Ketamine Do?

Mental health challenges and chronic pain conditions can be tough to manage, especially when traditional treatments fail to provide relief. Many patients seek our care after struggling with multiple medications, therapies, and lifestyle changes that have not delivered the desired results. To offer a new path toward healing, we provide an innovative, science-backed approach through ketamine therapy, helping individuals regain hope and improve their quality of life.

But what does ketamine do, and why is it gaining recognition as a breakthrough treatment? Ketamine has been widely recognized for its ability to rapidly alleviate symptoms of depression, anxiety, PTSD, and chronic pain. Unlike conventional treatments, which may take weeks to take effect, ketamine works swiftly to restore balance in the brain.

In this comprehensive guide, we explore what ketamine does, how it affects the brain and body, and what patients can expect from ketamine therapy at Renew Ketamine Infusion.

What Ketamine Does

Ketamine interacts with the brain and body in ways that differ from traditional antidepressants and pain relievers. Instead of simply masking symptoms, it reboots the brain’s neural connections, leading to lasting improvements in mood, cognition, and pain management.


Here are the key ways where ketamine makes a difference:

1. Restores Brain Connections:

Many mood disorders result from damaged or weakened neural connections. Ketamine promotes synaptogenesis, helping the brain form new, healthy pathways. This process enhances mood regulation, reducing feelings of sadness, anxiety, and hopelessness.

2. Provides Rapid Relief from Depression:

Unlike traditional antidepressants, which take weeks to work, ketamine can relieve depressive symptoms within hours. Studies show ‘what ketamine does’, which includes reduction in depressions, making it a potential lifesaving treatment.

3. Reduces Chronic Pain and Inflammation:

Ketamine blocks NMDA receptors, interrupting pain signals in the nervous system. It also has anti-inflammatory effects, which can help manage autoimmune and neuropathic pain conditions.

Patients with fibromyalgia, CRPS, migraines, and arthritis often experience significant relief.

4. Enhances Neuroplasticity:

Ketamine increases the brain’s ability to adapt and recover from the effects of trauma, stress, and depression. This allows for better emotional resilience, improved thinking, and a more remarkable ability to handle life’s challenges.

5. Alters Perception and Consciousness:

During treatment, some patients report experiencing a dream-like state or dissociation.

These effects help the brain “reset” and detach from deeply ingrained negative thought patterns.

We have seen these effects change lives. Patients who once felt hopeless report newfound optimism, energy, and motivation after undergoing ketamine therapy.

Understanding Ketamine: A Revolutionary Treatment

Ketamine was originally developed in the 1960s as an anesthetic and has been used in medical settings for decades. However, in recent years, researchers have discovered its incredible potential in mental health and pain management.

Many people ask, what does ketamine do that makes it different from traditional antidepressants? The key lies in how it interacts with the brain. Instead of targeting serotonin or dopamine like most antidepressants, ketamine works through the glutamate system, helping to repair and strengthen neural pathways that are often damaged in individuals with depression, anxiety, and PTSD.

We specialize in the safe and controlled administration of ketamine therapy, helping patients regain a sense of well-being and control over their lives.

How Ketamine Works in the Brain and Body

Ketamine’s effects on the brain are immediate and long-lasting, setting it apart from traditional treatments.

1. Impact on the Glutamine System

Ketamine primarily influences the glutamate system, which plays a critical role in neural communication, learning, and memory. More specifically, ketamine blocks NMDA receptors, increasing the release of glutamate, a neurotransmitter essential for brain function.

It triggers synaptogenesis, or the formation of new neural connections, which helps restore damaged pathways in the brain. It improves neuroplasticity, allowing the brain to adapt and function more efficiently, even in individuals with long-standing mental health conditions.

These changes can lead to rapid improvements in mood and cognition, often within hours of treatment.

2. The Role of Ketamine in Mental Health

Many mental health disorders, including depression and PTSD, are linked to disrupted neural pathways and decreased neuroplasticity. Traditional antidepressants attempt to correct these imbalances, but they can take weeks or even months to work—if they work at all.

 

Ketamine, on the other hand, has shown remarkable effectiveness in treating conditions such as:

  • Major Depressive Disorder (MDD) – Especially in individuals who have not responded to standard treatments.
  • Anxiety Disorders – Including generalized anxiety disorder (GAD) and social anxiety disorder.
  • Post-Traumatic Stress Disorder (PTSD) – By modulating memory processing, ketamine helps reduce the emotional impact of traumatic experiences.


At Renew Ketamine Infusion, we have seen firsthand how ketamine therapy transforms lives. Many patients report feeling lighter, more optimistic, and more engaged with life after just a few sessions.

3. Ketamine Helps With Chronic Pain

Beyond its mental health applications, ketamine is also a powerful tool for pain management. It is particularly effective for conditions that involve nerve dysfunction or central sensitization, including:

  • Neuropathic Pain – Conditions like fibromyalgia and complex regional pain syndrome (CRPS) that involve abnormal nerve signaling.
  • Migraines and Cluster Headaches – Ketamine helps interrupt pain pathways, relieving chronic headache sufferers.
  • Inflammatory Pain Conditions – Such as arthritis and autoimmune-related pain disorders, inflammation contributes to ongoing discomfort.

Unlike opioids, which can lead to dependency and tolerance, ketamine offers a non-addictive alternative for managing chronic pain while also improving mood and cognitive function.

What to Expect During a Ketamine Therapy

At Renew Ketamine Infusion, we take a patient-centered approach to treatment, ensuring comfort and safety at every step of the process. If you are considering ketamine therapy, here is what you can expect.

1. Pre-Treatment Consultation:

Before starting ketamine therapy, we conduct a thorough medical assessment to determine if the treatment is proper for you. This includes reviewing your medical history and current medications to avoid any potential interactions, discussing your symptoms and treatment goals to develop a personalized plan, and addressing any concerns or questions you may have about the procedure.

2. The Process:

Ketamine is administered intravenously (IV) over a period of 40-60 minutes. You will be seated in a comfortable treatment chair while our team monitors your vital signs. Some patients experience a dream-like state or mild dissociation, which typically fades after the process ends.

Throughout the session, our medical staff will be available to ensure you feel safe and supported.

3. Post-Treatment Recovery:

After the process, you will rest for a short period before leaving the clinic. Some patients report an immediate improvement in mood, while others notice gradual relief over the next 24-48 hours. Many individuals feel a renewed sense of motivation, mental clarity, and emotional balance following treatment. Since ketamine does not cause long-term sedation, most patients resume normal activities the next day. However, we recommend arranging for transportation home after each session, as some mild disorientation can occur.

How Quickly Does Ketamine Work?

One of the most compelling aspects of ketamine therapy is how rapidly it takes effect. While traditional antidepressants can take weeks to show results, ketamine works in as little as a few hours to a couple of days.


Typical Timeline of Ketamine Benefits:

  • Within Hours: Some patients notice a reduction in suicidal thoughts and an improved sense of calm.
  • 24-48 Hours: Mood, motivation, and overall well-being continue to improve.

After the therapy, many individuals report a significant decrease in symptoms and greater emotional stability.

We generally recommend a series of six initial treatments over two to three weeks, followed by maintenance as needed.

The Future of Ketamine Therapy

The medical community continues to explore new applications for ketamine therapy, with promising results in areas such as:

  • Obsessive-Compulsive Disorder (OCD) – Studies suggest ketamine may reduce obsessive thoughts and compulsive behaviors.
  • Bipolar Disorder – Providing relief for individuals experiencing depressive episodes.
  • Addiction Treatment – Researchers are investigating how ketamine can help break addiction cycles by rewiring neural pathways.

As ongoing research expands our understanding of ketamine’s benefits, we remain committed to providing our patients with the most advanced, evidence-based treatments available.

Why Choose Renew Ketamine?

Our mission is to help individuals reclaim their lives through innovative and effective treatments. With a team of experienced medical professionals specializing in ketamine therapy, we are committed to providing expert care and patient-centered support. Every individual receives a personalized treatment plan tailored to their specific needs, ensuring the best possible outcomes. 

Our state-of-the-art facility is designed to promote relaxation and healing, creating a comfortable and safe environment for treatment. Above all, we take a compassionate approach, prioritizing each patient’s well-being, comfort, and long-term success on their journey to better mental health and pain relief.

Take the Next Step Toward Healing

Struggling with depression, anxiety, PTSD, or chronic pain can be overwhelming, but there is hope. Ketamine therapy offers a new path toward relief, helping individuals regain control of their mental health and overall well-being. If you are looking for an effective solution, now is the time to explore the benefits of ketamine treatment. 

Contact us today to learn more about ketamine and how it can help you take the next step towards your healing journey.

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OCD

Obsessive Compulsive disorder (OCD) is unfortunately resistant to many forms of medical treatment including both medication and therapy.

Ketamine has been shown to be an effective, fast acting, safe option for patients with OCD. Over the course of the Ketamine infusions (2-4 weeks) neuroplasticity can lead to a change or abatement in the intrusive, repetitive thoughts and behaviors that typify OCD.

When combined with our unique post infusion integration process, patients with severe OCD can see profound relief of their symptoms.

Start here for a free physician consultation to see if Ketamine assisted psychotherapy can help renew you.

Chronic Pain

“There is extensive research currently being done on this topic. I can say from personal experience as a practicing Board Certified Pain Medicine Physician, I have had patients with chronic pain, including fibromyalgia, who have had significant relief of their symptoms with Ketamine assisted therapy. With that said, Ketamine assisted therapy will definitely not work for everyone with chronic pain, and each patient will require a thorough evaluation to ensure they are an adequate candidate for a trial of Ketamine assisted therapy for relief of their chronic pain” -Dr. Justin Yanuck.

The current evidence of Ketamine assisted therapy for chronic pain is fairly mixed. The majority of studies only looked at ketamine infusion without any assisted psychotherapy.

Ketamine has the ability to lead to relief on its own (and the mechanisms for this have been well studied). We feel quite strongly that the real potential for Ketamine to provide relief, especially for chronic pain patients, is when combined with psychotherapy. Psychotherapy allows the individual to process their experience and build off this experience to lead to new psychological frameworks for processing both internal and external stimuli.

Pain is complex, and Ketamine assisted psychotherapy is not one-size-fits-all. Our treatment plan gives patients with treatment-resistant chronic pain and even opiate dependance a chance to try a different and effective treatment. Start here (button) for a free physician consultation to see if Ketamine assisted psychotherapy can help renew you.

Start here for a free physician consultation to see if Ketamine assisted psychotherapy can help renew you.

PTSD

Post Traumatic Stress Disorder (PTSD) is a major public health concern, affecting up to 7% of Americans.

As many as half of all Americans with PTSD get inadequate relief from traditional treatments which include antidepressants, antipsychotics, and cognitive behavioral therapy.

Ketamine combined with psychotherapy has been shown to be very effective at reducing the symptoms of PTSD. These effects last well beyond its near immediate relief.

Many mechanistic actions for how Ketamine works in PTSD have been proposed.

Ketamine allows people to reacquaint themselves with their past inciting trauma from an emotionally neutral perspective. Ketamine will not make you forget about the trauma. It can allow you to acknowledge its occurrence in a neutral way in order to not be continually re-traumatized by thinking about it.

Depending on the patient, outcomes can be noticed almost immediately with a sense of lightness and joy. Ketamine followed by psychotherapy has been shown to lead to significant relief of the burdens of PTSD.

Start here for a free physician consultation to see if Ketamine assisted psychotherapy can help renew you.

Anxiety

Traditional treatments for anxiety will often either work poorly, have addictive properties, or severe side effects including brain fog and drowsiness. Furthermore, these treatments tend to have reduced efficacy over time, and lead to only transient relief of symptoms.

Ketamine, when combined with our novel integrative psychotherapy, can lead to significant relief of anxiety.

During the ketamine infusion and integration process, patients will often get a better understanding of their anxiety, and are able to reframe many of the triggers that often provoke their anxiety.

Ketamine has properties that allow for rewiring of the brain (new synapse formation and repair of existing synapses). Ketamine allows people to effect changes into their own lives. It shows people that they have the power to heal from within and take control of their relationship with anxiety.

Start here for a free physician consultation to see if Ketamine assisted psychotherapy can help renew you.

Depression

Ketamine has been shown to be extremely effective and safe for patients with depression and treatment resistant depression (those who fail to get relief from two or more antidepressants).

Ketamine is highly effective at rapidly (within 2-8 hours) reducing depressive symptoms. Traditional antidepressants often take weeks to months to work.

Many traditional antidepressants have side effects including reduced libido, weight gain, GI upset, mood disturbances, and unfortunately require daily use for months to years.

Many antidepressants, even if they do work, require you to be on them for years, if not for the rest of your life.

Ketamine treatment has been shown in most patients to lead to resolution of symptoms without the need for any further medications.

Ketamine is not a medication meant to be taken for the rest of your life. The goal is to provide sustained relief after the completion of a set treatment plan. This is accomplished by combining the actions of Ketamine in the brain with psychotherapy. Additional enhancement sessions available as needed.

Unfortunately, there is a significant subset of patients that do not get significant relief from traditional cognitive behavioral therapy. Ketamine acts as a catalyst to stimulate a patient’s innate capacity for psychological healing. This allows patients to overcome past experiences and learned behavior to truly heal. Ketamine, combined with therapists who are specifically trained to work with psychedelic therapies, can lead to profound breakthroughs and deep psychological healing.

Start here for a free physician consultation to see if Ketamine assisted psychotherapy can help renew you.

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