When someone hears about a new treatment for depression, one of the first questions that comes up is simple but important: “How long will it take to work?” We get it. If you’re struggling with depression or supporting someone who is, time feels like everything.
That’s exactly why so many people in our community are asking about Spravato. It’s gaining attention because it offers a new approach to treating depression, especially for those who haven’t found relief with traditional options. Today, we want to walk you through what we’ve seen, what to expect, and how Spravato may fit into your journey toward feeling better.
What Is Spravato?
Let’s start with the basics. Spravato is a brand name for esketamine, which is closely related to Ketamine. It’s an FDA-approved nasal spray designed for people with treatment-resistant depression or major depressive disorder with suicidal thoughts.
Unlike many oral antidepressants that target serotonin, Spravato acts on the brain’s glutamate system. This pathway plays a major role in learning, memory, and mood regulation. Because of that, many people experience relief in a completely different way than they did with previous medications.
The Timeline: When Might You Feel a Difference?
We always remind our patients that every person is unique. However, here’s what we generally see:
Initial Phase (First Few Sessions)
Many people start to notice a shift in their mood within the first one to two weeks. Some even feel a difference within the first 24 to 48 hours after their initial sessions. This doesn’t mean full relief happens immediately, but for some, there’s a noticeable sense of lightness or clarity that hadn’t been there before.
This early response is often what gives people hope. After feeling stuck for so long, even a small improvement can be a powerful sign of progress.
Ongoing Treatment (First Month)
Spravato is usually given twice a week for the first four weeks. During this time, most of our patients begin to see clearer patterns of improvement. It might show up as better sleep, reduced anxiety, fewer intrusive thoughts, or more motivation during the day.
The effects tend to build with each session. We monitor closely during this phase to make sure everything feels comfortable and supportive.
Stabilization Phase (Weeks 5–8 and Beyond)
After the first month, the treatment schedule usually shifts to once per week, and later to every other week, depending on how you’re feeling. During this period, improvements often become more stable and long-lasting.
People tell us they feel more emotionally balanced and find it easier to reconnect with their daily routines. The goal isn’t just temporary relief. It’s giving your brain enough support to build lasting resilience.
Why Spravato Feels Different for Many
If you’ve tried multiple antidepressants without much success, you’re not alone. One of the reasons we’re so passionate about Spravato ketamine treatment is that they offer a new angle, not just a different version of the same old thing.
Ketamine and its related forms, like Spravato, help “rewire” brain connections in a way that supports emotional healing. It’s not a cure-all, but it creates space for real progress. We’ve seen people who were once overwhelmed by depression start to feel like themselves again.
And we’ll be honest. That’s one of the most rewarding parts of what we do.
What We Want You to Know Before Starting
Choosing a new treatment path can feel intimidating, and we respect that. Here are a few things we always share with new patients considering Spravato:
- It’s okay to feel unsure. You don’t have to commit to anything right away. We’re here to talk and help you understand all your options.
- You’ll be monitored closely. During each session, our team is right there with you to make sure everything goes smoothly.
- It works best when combined with support. Spravato is powerful, but pairing it with therapy, healthy habits, and emotional support often leads to even better results.
You Don’t Have to Wait in Silence
If you’ve been wondering why nothing seems to help your depression, or if your current medications have hit a wall, it might be time to try something new.
You don’t have to keep waiting, hoping things will change on their own. Let’s take the next step together and talk about how Spravato ketamine treatment could fit into your story.
At Renew Ketamine Infusion, we’ve seen firsthand how lives can change when the right approach meets the right support. Let’s explore this path together. Reach out to us today. We’re ready when you are.
